PLINEST®: Advanced Polynucleotide Gel for Skin Rejuvenation

PLINEST® is a single-use, sterile, apyrogenic, viscoelastic polynucleotide gel designed for intradermal use. Derived from highly purified, natural fish sources, this gel boasts powerful moisturizing properties and trophic effects on fibroblasts, enhancing skin elasticity and firmness. Ideal for a variety of aesthetic applications, PLINEST® is versatile and effective in promoting skin health.

Key Benefits

  • Deep Moisturization: Enhances skin hydration and promotes a youthful appearance.
  • Elasticity & Firmness: Stimulates fibroblast activity, improving skin elasticity and firmness.
  • Versatile Application: Suitable for use on the scalp, face, neck, abdomen, and other areas.


PLINEST® is indicated for:

  • Improving skin turgidity, elasticity, and firmness.
  • Remodeling areas with a strong fibrous component, such as stretch marks and scars.


Each 2 ml pre-filled syringe contains:

  • Aqua
  • Polynucleotides (20 mg/ml)
  • Sodium chloride
  • Sodium phosphate
  • Disodium phosphate


Administration Guidelines

Administer PLINEST® via intradermal injection using a fine-gauge needle (30 G recommended). Suitable injection techniques include:

  • Linear threading
  • Serial punctures
  • Cross-linked

Non-Invasive Methods: PLINEST® can also be applied using modern techniques like electroporation and hydroelectrophoresis.


Procedure Tips:

  • Disinfect the treatment area thoroughly.
  • Massage gently post-injection for better product distribution.
  • Replace the needle halfway through the treatment to enhance patient comfort.


Avoid using PLINEST® in patients:

  • With hypersensitivity to any component.
  • With a history of fish allergies.
  • With autoimmune diseases, or who are pregnant, nursing, or under 18 years old.


  • Ensure intradermal injection only.
  • Avoid areas with infections, dermatitis, or inflammation.
  • Do not mix with other products.
  • Maintain standard infection control procedures.


1. What makes PLINEST® unique compared to other skin rejuvenation products?

PLINEST® uses highly purified polynucleotides derived from natural fish sources, offering superior moisturizing and trophic benefits that enhance skin elasticity and firmness.


2. Can PLINEST® be used in combination with other treatments?

PLINEST® should not be mixed with other products or used during the same treatment session with other products. Consult your physician for a personalized treatment plan.


3. What areas can be treated with PLINEST®?

PLINEST® can be used on various skin areas including the scalp, forehead, eye contour, face, neck, abdomen, buttocks, and thighs, depending on the doctor’s assessment.


4. How should the treatment area be prepared before administering PLINEST®?

Thoroughly disinfect the area with alcohol or another antiseptic before administering PLINEST®. After disinfection, ensure the area is clean to minimize infection risk.


5. What should be done if a patient experiences side effects after treatment?

Common side effects like minor blood effusions and transient red papules typically resolve quickly. If side effects such as erythema, pain, or heat sensation persist, advise the patient to consult a physician. Ensure patients report any unusual reactions promptly for proper treatment.

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