PLINEST® Eye: Advanced Polynucleotide Injectable for Periocular and Facial Rejuvenation

PLINEST® Eye is a sterile, viscoelastic, non-pyrogenic polynucleotide gel designed for single-use intradermal injection. Derived from highly purified, natural fish sources, this re-absorbable injectable gel offers exceptional moisturizing and trophic benefits. It enhances skin elasticity and tone, making it an essential treatment for periocular and facial rejuvenation in aesthetic clinics.


Key Benefits

  • Moisturizing & Trophic Effects: Promotes hydration and stimulates fibroblast activity for improved skin health and appearance.
  • Versatile Application: Suitable for sensitive and delicate areas such as the forehead, cheeks, and around the eyes.
  • Customizable Treatments: Allows for tailored protocols to address individual patient needs and conditions.


PLINEST® Eye is ideal for:

  • Improving skin firmness, elasticity, and tone.
  • Reshaping highly fibrous areas like scars and striae.


Each 2 ml pre-filled syringe contains:

  • Aqua
  • 0.75% polynucleotides
  • Sodium chloride
  • Sodium phosphate
  • Disodium phosphate

Administration Guidelines

Administer PLINEST® Eye via intradermal injection using a fine-gauge needle (30 G recommended). Suitable injection techniques include:

  • Microinjections
  • Retrograde linear

Non-Invasive Methods: PLINEST® Eye can also be applied using iontophoresis, electroporation, and other modern techniques.


Procedure Tips:

  • Disinfect the treatment area thoroughly.
  • Massage gently post-injection for better distribution.
  • Replace the needle halfway through the treatment to enhance patient comfort.


Avoid using PLINEST® Eye in patients:

  • With hypersensitivity to any component.
  • With a history of fish allergies.
  • With autoimmune diseases, or who are pregnant, nursing, or under 18 years old.


  • Ensure intradermal injection only.
  • Avoid areas with infections, dermatitis, or inflammation.
  • Do not mix with other products.
  • Maintain standard infection control procedures.


1. How does PLINEST® Eye differ from other periocular rejuvenation injectables?

PLINEST® Eye is derived from highly purified, natural fish sources and offers exceptional moisturizing and trophic benefits. It promotes hydration and fibroblast activity, enhancing skin elasticity and tone, particularly in sensitive areas like the periocular region.


2. Can PLINEST® Eye be used on patients with previous facial treatments?

Yes, PLINEST® Eye can be used on patients who have undergone previous facial treatments. However, ensure that the patient’s skin has returned to its normal physiological state before administering PLINEST® Eye.


3. What areas can be treated with PLINEST® Eye?

PLINEST® Eye can be used on sensitive and delicate skin areas, including the forehead, cheeks, and around the eyes. It is particularly effective for improving skin firmness, elasticity, and tone.


4. How should the treatment area be prepared before administering PLINEST® Eye?

Thoroughly disinfect the area with alcohol or another antiseptic. After disinfection, remove any disinfectant residue with sterile saline solution to minimize infection risk.


5. What should be done if a patient experiences side effects after treatment?

Common side effects like minor blood effusions and transient swelling typically resolve quickly. If side effects such as erythema, pain, or heat sensation persist, advise the patient to consult a physician. Ensure patients report any unusual reactions promptly for proper treatment.

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